| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity tyrosine-phosphorylation-regulated kinase 1B |
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| Ligand | BDBM50466164 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1791713 (CHEMBL4263632) |
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| IC50 | 299±n/a nM |
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| Citation |  Darwish, SS; Abdel-Halim, M; Salah, M; Abadi, AH; Becker, W; Engel, M Development of novel 2,4-bispyridyl thiophene-based compounds as highly potent and selective Dyrk1A inhibitors. Part I: Benzamide and benzylamide derivatives. Eur J Med Chem157:1031-1050 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity tyrosine-phosphorylation-regulated kinase 1B |
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| Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 1B |
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| Synonyms: | DYR1B_HUMAN | DYRK1B | Dual specificity tyrosine-phosphorylation-regulated kinase 1B | Dual-specificity tyrosine-regulated kinases 1B | MIRK |
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| Type: | Enzyme |
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| Mol. Mass.: | 69222.24 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y463 |
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| Residue: | 629 |
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| Sequence: | MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN
EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG
SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF
MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL
KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG
CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT
KELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARI
SPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDN
RTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGA
QLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGR
PPLPPPDDPATLGPHLGLRGVPQSTAASS
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| BDBM50466164 |
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| n/a |
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| Name | BDBM50466164 |
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| Synonyms: | CHEMBL4283474 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H12F3N3OS |
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| Mol. Mass. | 411.4 |
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| SMILES | Fc1cc(F)c(C(=O)Nc2cncc(c2)-c2cc(cs2)-c2cccnc2)c(F)c1 |
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| Structure | 
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