| Reaction Details |
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 | Report a problem with these data |
| Target | Bone morphogenetic protein receptor type-1A |
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| Ligand | BDBM50466190 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1792059 (CHEMBL4263978) |
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| IC50 | 3466±n/a nM |
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| Citation |  Jiang, JK; Huang, X; Shamim, K; Patel, PR; Lee, A; Wang, AQ; Nguyen, K; Tawa, G; Cuny, GD; Yu, PB; Zheng, W; Xu, X; Sanderson, P; Huang, W Discovery of 3-(4-sulfamoylnaphthyl)pyrazolo[1,5-a]pyrimidines as potent and selective ALK2 inhibitors. Bioorg Med Chem Lett28:3356-3362 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bone morphogenetic protein receptor type-1A |
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| Name: | Bone morphogenetic protein receptor type-1A |
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| Synonyms: | ACVRLK3 | ALK3 | Activin receptor-like kinase 3 (ALK-3) | BMPR1A | BMR1A_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 60204.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P36894 |
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| Residue: | 532 |
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| Sequence: | MPQLYIYIRLLGAYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLK
CYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRR
TIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYC
KSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQV
GKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTG
SWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAH
RDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKN
HFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLR
PIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI
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| BDBM50466190 |
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| n/a |
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| Name | BDBM50466190 |
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| Synonyms: | CHEMBL4288921 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H28N6O2S |
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| Mol. Mass. | 512.626 |
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| SMILES | C[C@H]1CNC[C@@H](C)N1c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccc(c2ccccc12)S(N)(=O)=O |r| |
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| Structure | 
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