| Reaction Details |
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 | Report a problem with these data |
| Target | Dopamine beta-hydroxylase |
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| Ligand | BDBM50014960 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_59102 (CHEMBL667895) |
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| IC50 | 32000±n/a nM |
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| Citation |  Kruse, LI; Kaiser, C; DeWolf, WE; Frazee, JS; Garvey, E; Hilbert, EL; Faulkner, WA; Flaim, KE; Sawyer, JL; Berkowitz, BA Multisubstrate inhibitors of dopamine beta-hydroxylase. 1. Some 1-phenyl and 1-phenyl-bridged derivatives of imidazole-2-thione. J Med Chem29:2465-72 (1987) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dopamine beta-hydroxylase |
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| Name: | Dopamine beta-hydroxylase |
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| Synonyms: | DBH | DOPO_BOVIN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 68136.39 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_50738 |
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| Residue: | 610 |
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| Sequence: | MQVPSPSVREAASMYGTAVAVFLVILVAALQGSAPAESPFPFHIPLDPEGTLELSWNISY
AQETIYFQLLVRELKAGVLFGMSDRGELENADLVVLWTDRDGAYFGDAWSDQKGQVHLDS
QQDYQLLRAQRTPEGLYLLFKRPFGTCDPNDYLIEDGTVHLVYGFLEEPLRSLESINTSG
LHTGLQRVQLLKPSIPKPALPADTRTMEIRAPDVLIPGQQTTYWCYVTELPDGFPRHHIV
MYEPIVTEGNEALVHHMEVFQCAAEFETIPHFSGPCDSKMKPQRLNFCRHVLAAWALGAK
AFYYPEEAGLAFGGPGSSRFLRLEVHYHNPLVITGRRDSSGIRLYYTAALRRFDAGIMEL
GLAYTPVMAIPPQETAFVLTGYCTDKCTQLALPASGIHIFASQLHTHLTGRKVVTVLARD
GRETEIVNRDNHYSPHFQEIRMLKKVVSVQPGDVLITSCTYNTEDRRLATVGGFGILEEM
CVNYVHYYPQTQLELCKSAVDPGFLHKYFRLVNRFNSEEVCTCPQASVPEQFASVPWNSF
NREVLKALYGFAPISMHCNRSSAVRFQGEWNRQPLPEIVSRLEEPTPHCPASQAQSPAGP
TVLNISGGKG
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|
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| BDBM50014960 |
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| n/a |
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| Name | BDBM50014960 |
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| Synonyms: | 1-Benzyl-1,3-dihydro-imidazole-2-thione | 1-Benzyl-1H-imidazole-2-thiol | CHEMBL164791 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H10N2S |
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| Mol. Mass. | 190.265 |
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| SMILES | S=c1[nH]ccn1Cc1ccccc1 |
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| Structure | 
|
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