| Reaction Details |
|---|
 | Report a problem with these data |
| Target | E3 ubiquitin-protein ligase Mdm2 |
|---|
| Ligand | BDBM129722 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1795643 (CHEMBL4267760) |
|---|
| IC50 | 0.140000±n/a nM |
|---|
| Citation |  Vaupel, A; Holzer, P; Ferretti, S; Guagnano, V; Kallen, J; Mah, R; Masuya, K; Ruetz, S; Rynn, C; Schlapbach, A; Stachyra, T; Stutz, S; Todorov, M; Jeay, S; Furet, P In vitro and in vivo characterization of a novel, highly potent p53-MDM2 inhibitor. Bioorg Med Chem Lett28:3404-3408 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| E3 ubiquitin-protein ligase Mdm2 |
|---|
| Name: | E3 ubiquitin-protein ligase Mdm2 |
|---|
| Synonyms: | Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein |
|---|
| Type: | Oncoprotein |
|---|
| Mol. Mass.: | 55196.54 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q00987 |
|---|
| Residue: | 491 |
|---|
| Sequence: | MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVP
DCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQ
DKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQ
PIQMIVLTYFP
|
|
|
|---|
| BDBM129722 |
|---|
| n/a |
|---|
| Name | BDBM129722 |
|---|
| Synonyms: | US8815926, 1 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H26Cl2FN3O2 |
|---|
| Mol. Mass. | 538.44 |
|---|
| SMILES | COc1ccc(F)cc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C |
|---|
| Structure | 
|
|---|
Search and Browse
