| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H3 receptor |
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| Ligand | BDBM50475344 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_304041 (CHEMBL840219) |
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| Ki | 50±n/a nM |
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| Citation |  Kitbunnadaj, R; Hashimoto, T; Poli, E; Zuiderveld, OP; Menozzi, A; Hidaka, R; de Esch, IJ; Bakker, RA; Menge, WM; Yamatodani, A; Coruzzi, G; Timmerman, H; Leurs, R N-substituted piperidinyl alkyl imidazoles: discovery of methimepip as a potent and selective histamine H3 receptor agonist. J Med Chem48:2100-7 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H3 receptor |
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| Name: | Histamine H3 receptor |
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| Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48691.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Binding assays were using CHO cells stably expressing hH3R receptors. |
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| Residue: | 445 |
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| Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
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| BDBM50475344 |
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| n/a |
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| Name | BDBM50475344 |
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| Synonyms: | CHEMBL175741 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H17N3 |
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| Mol. Mass. | 191.2728 |
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| SMILES | CCN1CCC(CC1)=Cc1c[nH]cn1 |(5.08,1,;3.98,2.07,;2.5,1.67,;2.1,.19,;.61,-.22,;-.48,.88,;-.09,2.35,;1.43,2.77,;-1.99,.53,;-2.43,-.94,;-3.79,-1.6,;-3.59,-3.14,;-2.1,-3.42,;-1.36,-2.06,)| |
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| Structure | 
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