| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tubulin beta chain |
|---|
| Ligand | BDBM4810 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_326923 (CHEMBL854312) |
|---|
| IC50 | >40000±n/a nM |
|---|
| Citation |  Li, PK; Xiao, Z; Hu, Z; Pandit, B; Sun, Y; Sackett, DL; Werbovetz, K; Lewis, A; Johnsamuel, J Conformationally restricted analogs of Combretastatin A-4 derived from SU5416. Bioorg Med Chem Lett15:5382-5 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tubulin beta chain |
|---|
| Name: | Tubulin beta chain |
|---|
| Synonyms: | Beta-tubulin | TBB_PIG | Tubulin beta chain |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 49840.26 |
|---|
| Organism: | Sus scrofa |
|---|
| Description: | ChEMBL_105107 |
|---|
| Residue: | 445 |
|---|
| Sequence: | MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEGEEDEA
|
|
|
|---|
| BDBM4810 |
|---|
| n/a |
|---|
| Name | BDBM4810 |
|---|
| Synonyms: | (3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-2,3-dihydro-1H-indol-2-one | 3-[(2,4-dimethylpyrrol-5-yl)methylidenyl]-indolin-2-one | CHEMBL276711 | SU5146 | SU5416 | Semaxanib | US10189853, semaxanib | US11111252, Compound SU5416 | US9422297, SU5416 | cid_5329098 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H14N2O |
|---|
| Mol. Mass. | 238.2845 |
|---|
| SMILES | Cc1cc(C)c(\C=C2/C(=O)Nc3ccccc23)[nH]1 |
|---|
| Structure | 
|
|---|
Search and Browse
