| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase |
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| Ligand | BDBM50478098 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_468352 (CHEMBL931815) |
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| IC50 | 600±n/a nM |
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| Citation |  Boojamra, CG; Mackman, RL; Markevitch, DY; Prasad, V; Ray, AS; Douglas, J; Grant, D; Kim, CU; Cihlar, T Synthesis and anti-HIV activity of GS-9148 (2'-Fd4AP), a novel nucleoside phosphonate HIV reverse transcriptase inhibitor. Bioorg Med Chem Lett18:1120-3 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Reverse transcriptase |
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| Name: | Reverse transcriptase |
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| Synonyms: | n/a |
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| Type: | Protein |
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| Mol. Mass.: | 29598.37 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | Q9WKE8 |
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| Residue: | 254 |
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| Sequence: | PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVF
AIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLD
KDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY
QYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTV
QPIVLPEKDSWTVN
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| BDBM50478098 |
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| n/a |
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| Name | BDBM50478098 |
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| Synonyms: | CHEMBL420843 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H12N5O5P |
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| Mol. Mass. | 313.2065 |
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| SMILES | Nc1ncnc2n(cnc12)[C@@H]1O[C@H](OCP(O)(O)=O)C=C1 |r,c:21| |
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| Structure | 
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