| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase |
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| Ligand | BDBM50480228 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_545205 (CHEMBL1018956) |
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| IC50 | 700±n/a nM |
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| Citation |  Spallarossa, A; Cesarini, S; Ranise, A; Schenone, S; Bruno, O; Borassi, A; La Colla, P; Pezzullo, M; Sanna, G; Collu, G; Secci, B; Loddo, R Parallel synthesis, molecular modelling and further structure-activity relationship studies of new acylthiocarbamates as potent non-nucleoside HIV-1 reverse transcriptase inhibitors. Eur J Med Chem44:2190-201 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Reverse transcriptase |
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| Name: | Reverse transcriptase |
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| Synonyms: | n/a |
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| Type: | Protein |
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| Mol. Mass.: | 29598.37 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | Q9WKE8 |
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| Residue: | 254 |
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| Sequence: | PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVF
AIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLD
KDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY
QYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTV
QPIVLPEKDSWTVN
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| BDBM50480228 |
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| n/a |
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| Name | BDBM50480228 |
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| Synonyms: | CHEMBL484982 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H15BrClN3O4S |
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| Mol. Mass. | 544.805 |
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| SMILES | Clc1ncccc1C(=O)N(C(=S)OCCN1C(=O)c2ccccc2C1=O)c1ccc(Br)cc1 |
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| Structure | 
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