Reaction Details |
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Target | Reverse transcriptase protein |
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Ligand | BDBM50482297 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_640766 (CHEMBL1175707) |
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IC50 | 69±n/a nM |
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Citation | Kertesz, DJ; Brotherton-Pleiss, C; Yang, M; Wang, Z; Lin, X; Qiu, Z; Hirschfeld, DR; Gleason, S; Mirzadegan, T; Dunten, PW; Harris, SF; Villaseņor, AG; Hang, JQ; Heilek, GM; Klumpp, K Discovery of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-benzyl derivatives with broad potency against resistant mutant viruses. Bioorg Med Chem Lett20:4215-8 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Reverse transcriptase protein |
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Name: | Reverse transcriptase protein |
Synonyms: | Reverse Transcriptase | Reverse Transcriptase (A62V) | Reverse Transcriptase (F61A) |
Type: | Protein |
Mol. Mass.: | 30203.56 |
Organism: | Human immunodeficiency virus 1 |
Description: | Q9WJQ2 |
Residue: | 259 |
Sequence: | PISPIEPVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKRSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLWMGYEHHPDKWT
VQPIVLPEKDSWTVNDIQK
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BDBM50482297 |
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n/a |
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Name | BDBM50482297 |
Synonyms: | CHEMBL1169982 |
Type | Small organic molecule |
Emp. Form. | C26H26BrClN6O2 |
Mol. Mass. | 569.881 |
SMILES | Cc1cc(cc(C)c1Oc1nc(NC2CCN(Cc3ccc(cc3Cl)C(N)=O)CC2)ncc1Br)C#N |
Structure |
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