| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase |
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| Ligand | BDBM50482309 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_640765 (CHEMBL1175706) |
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| IC50 | 152±n/a nM |
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| Citation |  Kertesz, DJ; Brotherton-Pleiss, C; Yang, M; Wang, Z; Lin, X; Qiu, Z; Hirschfeld, DR; Gleason, S; Mirzadegan, T; Dunten, PW; Harris, SF; Villaseņor, AG; Hang, JQ; Heilek, GM; Klumpp, K Discovery of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-benzyl derivatives with broad potency against resistant mutant viruses. Bioorg Med Chem Lett20:4215-8 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Reverse transcriptase |
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| Name: | Reverse transcriptase |
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| Synonyms: | n/a |
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| Type: | Protein |
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| Mol. Mass.: | 29598.37 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | Q9WKE8 |
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| Residue: | 254 |
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| Sequence: | PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVF
AIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLD
KDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY
QYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTV
QPIVLPEKDSWTVN
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| BDBM50482309 |
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| n/a |
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| Name | BDBM50482309 |
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| Synonyms: | CHEMBL1170018 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H25BrClN5O |
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| Mol. Mass. | 526.856 |
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| SMILES | Cc1cc(cc(C)c1Oc1nc(NC2CCN(Cc3ccc(Cl)cc3)CC2)ncc1Br)C#N |
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| Structure | 
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