| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase |
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| Ligand | BDBM50483001 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_675251 (CHEMBL1273233) |
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| IC50 | 500±n/a nM |
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| Citation |  Liu, B; Lee, Y; Zou, J; Petrassi, HM; Joseph, RW; Chao, W; Michelotti, EL; Bukhtiyarova, M; Springman, EB; Dorsey, BD Discovery and SAR of a series of 4,6-diamino-1,3,5-triazin-2-ol as novel non-nucleoside reverse transcriptase inhibitors of HIV-1. Bioorg Med Chem Lett20:6592-6 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Reverse transcriptase |
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| Name: | Reverse transcriptase |
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| Synonyms: | n/a |
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| Type: | Protein |
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| Mol. Mass.: | 29598.37 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | Q9WKE8 |
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| Residue: | 254 |
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| Sequence: | PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVF
AIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLD
KDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY
QYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTV
QPIVLPEKDSWTVN
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| BDBM50483001 |
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| n/a |
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| Name | BDBM50483001 |
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| Synonyms: | CHEMBL1271043 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H22N6O |
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| Mol. Mass. | 422.4818 |
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| SMILES | Cc1cccc(-c2ccccc2)c1Nc1nc(O)nc(NCc2ccc3cc[nH]c3c2)n1 |
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| Structure | 
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