| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase |
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| Ligand | BDBM50033883 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_741508 (CHEMBL1769291) |
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| IC50 | >40000±n/a nM |
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| Citation |  La Regina, G; Coluccia, A; Brancale, A; Piscitelli, F; Gatti, V; Maga, G; Samuele, A; Pannecouque, C; Schols, D; Balzarini, J; Novellino, E; Silvestri, R Indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: new cyclic substituents at indole-2-carboxamide. J Med Chem54:1587-98 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Reverse transcriptase |
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| Name: | Reverse transcriptase |
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| Synonyms: | n/a |
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| Type: | Protein |
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| Mol. Mass.: | 29598.37 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | Q9WKE8 |
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| Residue: | 254 |
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| Sequence: | PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVF
AIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLD
KDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY
QYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTV
QPIVLPEKDSWTVN
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| BDBM50033883 |
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| n/a |
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| Name | BDBM50033883 |
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| Synonyms: | CHEMBL1766221 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H21ClN2O3S |
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| Mol. Mass. | 452.953 |
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| SMILES | Cc1cc(C)cc(c1)S(=O)(=O)c1c([nH]c2ccc(Cl)cc12)C(=O)NCc1ccccc1 |
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| Structure | 
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