| Reaction Details |
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 | Report a problem with these data |
| Target | Uridine phosphorylase 1 |
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| Ligand | BDBM50031003 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_212951 (CHEMBL873996) |
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| IC50 | 21100±n/a nM |
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| Citation |  Orr, GF; Musso, DL; Boswell, GE; Kelley, JL; Joyner, SS; Davis, ST; Baccanari, DP Inhibition of uridine phosphorylase: synthesis and structure-activity relationships of aryl-substituted 5-benzyluracils and 1-[(2-hydroxyethoxy)methyl]-5-benzyluracils. J Med Chem38:3850-6 (1995) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Uridine phosphorylase 1 |
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| Name: | Uridine phosphorylase 1 |
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| Synonyms: | UPP1_MOUSE | Up | Upp | Upp1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 34086.29 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_212951 |
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| Residue: | 311 |
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| Sequence: | MAATGTEAKDLENHHNDCFIQLSNPNIAAMKEDVLYHFNLSTSTHDFPAMFGDVKFVCVG
GSSSRMNTFIKYVAAELGLDHPGKEYPNICAGTDRYAMYKAGPVLSVSHGMGIPSIGIML
HELIKMLYHARCSNITIIRIGTSGGIGLEPGSVVITQQAVNECFKPEFEQIVLGKRVIRN
TNLDAQLVQELVQCSSDLNEFPMVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQSYLRAA
HAAGVRNIEMESSVFATMCSACGLKAAVVCVTLLDRLQGDQINTPHDVLVEYQQRPQRLV
GHFIKKSLGRA
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| BDBM50031003 |
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| n/a |
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| Name | BDBM50031003 |
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| Synonyms: | 4-(2,4-Dioxo-1,2,3,4-tetrahydro-pyrimidin-5-ylmethyl)-benzonitrile | CHEMBL124860 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H9N3O2 |
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| Mol. Mass. | 227.2188 |
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| SMILES | O=c1[nH]cc(Cc2ccc(cc2)C#N)c(=O)[nH]1 |
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| Structure | 
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