| Reaction Details |
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 | Report a problem with these data |
| Target | Integrase |
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| Ligand | BDBM50492497 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_969976 (CHEMBL2405242) |
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| IC50 | 5.0±n/a nM |
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| Citation |  Johns, BA; Kawasuji, T; Weatherhead, JG; Taishi, T; Temelkoff, DP; Yoshida, H; Akiyama, T; Taoda, Y; Murai, H; Kiyama, R; Fuji, M; Tanimoto, N; Jeffrey, J; Foster, SA; Yoshinaga, T; Seki, T; Kobayashi, M; Sato, A; Johnson, MN; Garvey, EP; Fujiwara, T Carbamoyl pyridone HIV-1 integrase inhibitors 3. A diastereomeric approach to chiral nonracemic tricyclic ring systems and the discovery of dolutegravir (S/GSK1349572) and (S/GSK1265744). J Med Chem56:5901-16 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Integrase |
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| Name: | Integrase |
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| Synonyms: | pol |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32203.43 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_106649 |
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| Residue: | 288 |
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| Sequence: | FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
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| BDBM50492497 |
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| n/a |
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| Name | BDBM50492497 |
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| Synonyms: | CHEMBL2403118 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H20FN3O5 |
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| Mol. Mass. | 401.3883 |
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| SMILES | [H][C@]12Cn3cc(C(=O)NCc4ccc(F)cc4)c(=O)c(O)c3C(=O)N1CC[C@@H](C)O2 |r| |
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| Structure | 
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