Reaction Details |
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Target | Acyl-CoA:cholesterol acyltransferase |
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Ligand | BDBM50047517 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_28333 (CHEMBL645897) |
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IC50 | 54±n/a nM |
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Citation | Kimura, T; Takase, Y; Hayashi, K; Tanaka, H; Ohtsuka, I; Saeki, T; Kogushi, M; Yamada, T; Fujimori, T; Saitou, I Structure-activity relationship of N-[2-(dimethylamino)-6-[3-(5-methyl-4-phenyl-1H-imidazol-1-yl)propoxy] phenyl]-N'-pentylurea and analogues. Novel potent inhibitors of acyl-CoA:cholesterol O-acyltransferase with antiatherosclerotic activity. J Med Chem36:1630-40 (1993) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Acyl-CoA:cholesterol acyltransferase |
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Name: | Acyl-CoA:cholesterol acyltransferase |
Synonyms: | ACAT |
Type: | n/a |
Mol. Mass.: | 35405.31 |
Organism: | Oryctolagus cuniculus |
Description: | n/a |
Residue: | 305 |
Sequence: | PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIF
VARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLP
TVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYI
VLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLF
APTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVL
VLCIF
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BDBM50047517 |
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n/a |
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Name | BDBM50047517 |
Synonyms: | 1-(2-{3-[4-(4-Butyl-phenyl)-imidazol-1-yl]-propoxy}-6-dimethylamino-phenyl)-3-pentyl-urea | CHEMBL43505 |
Type | Small organic molecule |
Emp. Form. | C30H43N5O2 |
Mol. Mass. | 505.6947 |
SMILES | CCCCCNC(=O)Nc1c(OCCCn2cnc(c2)-c2ccc(CCCC)cc2)cccc1N(C)C |
Structure |
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