Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Acyl-CoA:cholesterol acyltransferase |
---|
Ligand | BDBM50047528 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_28333 (CHEMBL645897) |
---|
IC50 | 180±n/a nM |
---|
Citation | Kimura, T; Takase, Y; Hayashi, K; Tanaka, H; Ohtsuka, I; Saeki, T; Kogushi, M; Yamada, T; Fujimori, T; Saitou, I Structure-activity relationship of N-[2-(dimethylamino)-6-[3-(5-methyl-4-phenyl-1H-imidazol-1-yl)propoxy] phenyl]-N'-pentylurea and analogues. Novel potent inhibitors of acyl-CoA:cholesterol O-acyltransferase with antiatherosclerotic activity. J Med Chem36:1630-40 (1993) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Acyl-CoA:cholesterol acyltransferase |
---|
Name: | Acyl-CoA:cholesterol acyltransferase |
Synonyms: | ACAT |
Type: | n/a |
Mol. Mass.: | 35405.31 |
Organism: | Oryctolagus cuniculus |
Description: | n/a |
Residue: | 305 |
Sequence: | PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIF
VARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLP
TVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYI
VLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLF
APTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVL
VLCIF
|
|
|
BDBM50047528 |
---|
n/a |
---|
Name | BDBM50047528 |
Synonyms: | 1-[2-(3-Benzoimidazol-1-yl-propoxy)-6-dimethylamino-phenyl]-3-pentyl-urea | CHEMBL40516 |
Type | Small organic molecule |
Emp. Form. | C24H33N5O2 |
Mol. Mass. | 423.5511 |
SMILES | CCCCCNC(=O)Nc1c(OCCCn2cnc3ccccc23)cccc1N(C)C |
Structure |
|