Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50049896 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_54280 (CHEMBL669873) |
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Ki | 30±n/a nM |
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Citation | Kuyper, LF; Baccanari, DP; Jones, ML; Hunter, RN; Tansik, RL; Joyner, SS; Boytos, CM; Rudolph, SK; Knick, V; Wilson, HR; Caddell, JM; Friedman, HS; Comley, JC; Stables, JN High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size. J Med Chem39:892-903 (1996) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 21453.99 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant human DHFR. |
Residue: | 187 |
Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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BDBM50049896 |
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n/a |
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Name | BDBM50049896 |
Synonyms: | 8-Butyl-7-tert-butyl-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine | CHEMBL171629 |
Type | Small organic molecule |
Emp. Form. | C18H25N5 |
Mol. Mass. | 311.4246 |
SMILES | CCCCc1cc2c(ccc3nc(N)nc(N)c23)n1C(C)(C)C |
Structure |
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