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TargetHistone-lysine N-methyltransferase SMYD3
LigandBDBM378488
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1576443 (CHEMBL3803120)
IC50 6800±n/a nM
Citation Mitchell, LHBoriack-Sjodin, PASmith, SThomenius, MRioux, NMunchhof, MMills, JEKlaus, CTotman, JRiera, TVRaimondi, AJacques, SLWest, KFoley, MWaters, NJKuntz, KWWigle, TJScott, MPCopeland, RASmith, JJChesworth, R Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor. ACS Med Chem Lett7:134-8 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histone-lysine N-methyltransferase SMYD3
Name:Histone-lysine N-methyltransferase SMYD3
Synonyms:SET and MYND domain-containing protein 3 | SMYD3 | SMYD3_HUMAN | ZMYND1 | ZNFN3A1 | Zinc finger MYND domain-containing protein 1
Type:Enzyme
Mol. Mass.:49101.22
Organism:Homo sapiens (Human)
Description:Q9H7B4-2
Residue:428
Sequence:
MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLM
RCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSES
EKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVIC
NSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYL
DMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHW
KWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRI
FFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEE
CDANIRAS
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  Blast E-value cutoff:
BDBM378488
n/a
NameBDBM378488
Synonyms:N-(1-((3-aminopropyl)sulfonyl)piperidin-4-yl)-6-chloro-2-oxoindoline-5-carboxamide | US10266526, Compound 621
TypeSmall organic molecule
Emp. Form.C17H23ClN4O4S
Mol. Mass.414.907
SMILESNCCCS(=O)(=O)N1CCC(CC1)NC(=O)c1cc2CC(=O)Nc2cc1Cl
Structure
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