| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone deacetylase 1 |
|---|
| Ligand | BDBM50121211 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1822322 (CHEMBL4322086) |
|---|
| IC50 | >100000±n/a nM |
|---|
| Citation |  Wu, G; Zhao, T; Kang, D; Zhang, J; Song, Y; Namasivayam, V; Kongsted, J; Pannecouque, C; De Clercq, E; Poongavanam, V; Liu, X; Zhan, P Overview of Recent Strategic Advances in Medicinal Chemistry. J Med Chem62:9375-9414 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone deacetylase 1 |
|---|
| Name: | Histone deacetylase 1 |
|---|
| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 55090.27 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q13547 |
|---|
| Residue: | 482 |
|---|
| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
|
|
|
|---|
| BDBM50121211 |
|---|
| n/a |
|---|
| Name | BDBM50121211 |
|---|
| Synonyms: | CHEMBL3622375 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H18N6O3S |
|---|
| Mol. Mass. | 434.471 |
|---|
| SMILES | Nc1ccccc1NC(=O)c1ccc(s1)-c1cn(CCc2cccc(c2)[N+]([O-])=O)nn1 |
|---|
| Structure | 
|
|---|
Search and Browse
