| Reaction Details |
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 | Report a problem with these data |
| Target | Prolyl hydroxylase EGLN3 |
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| Ligand | BDBM50507421 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1829981 (CHEMBL4329855) |
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| IC50 | 6.6±n/a nM |
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| Citation |  Liu, P; Wang, L; DuBois, BG; Colandrea, VJ; Liu, R; Cai, J; Du, X; Quan, W; Morris, W; Bai, J; Bishwokarma, B; Cheng, M; Piesvaux, J; Ray, K; Alpert, C; Chiu, CS; Zielstorff, M; Metzger, JM; Yang, L; Leung, D; Alleyne, C; Vincent, SH; Pucci, V; Li, X; Crespo, A; Stickens, D; Hale, JJ; Ujjainwalla, F; Sinz, CJ Discovery of Orally Bioavailable and Liver-Targeted Hypoxia-Inducible Factor Prolyl Hydroxylase (HIF-PHD) Inhibitors for the Treatment of Anemia. ACS Med Chem Lett9:1193-1198 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prolyl hydroxylase EGLN3 |
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| Name: | Prolyl hydroxylase EGLN3 |
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| Synonyms: | EGLN3 | EGLN3_HUMAN | Egl nine homolog 3 (EGLIN3) | Egl nine homolog 3 (EGLN3) |
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| Type: | Protein |
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| Mol. Mass.: | 27265.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9H6Z9 |
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| Residue: | 239 |
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| Sequence: | MPLGHIMRLDLEKIALEYIVPCLHEVGFCYLDNFLGEVVGDCVLERVKQLHCTGALRDGQ
LAGPRAGVSKRHLRGDQITWIGGNEEGCEAISFLLSLIDRLVLYCGSRLGKYYVKERSKA
MVACYPGNGTGYVRHVDNPNGDGRCITCIYYLNKNWDAKLHGGILRIFPEGKSFIADVEP
IFDRLLFFWSDRRNPHEVQPSYATRYAMTVWYFDAEERAEAKKKFRNLTRKTESALTED
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| BDBM50507421 |
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| n/a |
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| Name | BDBM50507421 |
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| Synonyms: | CHEMBL4462741 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H13F3N2O6 |
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| Mol. Mass. | 398.2901 |
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| SMILES | OC(=O)CNC(=O)c1c(O)c2COCc2n(Cc2cc(F)c(F)cc2F)c1=O |
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| Structure | 
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