| Reaction Details |
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 | Report a problem with these data |
| Target | Bromodomain-containing protein 4 |
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| Ligand | BDBM50508328 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1832467 (CHEMBL4332475) |
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| IC50 | 267±n/a nM |
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| Citation |  Sperandio, D; Aktoudianakis, V; Babaoglu, K; Chen, X; Elbel, K; Chin, G; Corkey, B; Du, J; Jiang, B; Kobayashi, T; Mackman, R; Martinez, R; Yang, H; Zablocki, J; Kusam, S; Jordan, K; Webb, H; Bates, JG; Lad, L; Mish, M; Niedziela-Majka, A; Metobo, S; Sapre, A; Hung, M; Jin, D; Fung, W; Kan, E; Eisenberg, G; Larson, N; Newby, ZER; Lansdon, E; Tay, C; Neve, RM; Shevick, SL; Breckenridge, DG Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor. Bioorg Med Chem27:457-469 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bromodomain-containing protein 4 |
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| Name: | Bromodomain-containing protein 4 |
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| Synonyms: | BRD4 | BRD4_HUMAN | Bromodomain-containing protein 4 (BRD4) | HUNK1 | Protein HUNK1 |
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| Type: | Protein |
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| Mol. Mass.: | 152264.84 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O60885 |
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| Residue: | 1362 |
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| Sequence: | MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPNKPKRQT
NQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYW
NAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGRG
RGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMT
VVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTI
DPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSKVSEQLKCCSGI
LKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGA
DVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVV
APPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKE
KDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYE
SEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLK
PSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETE
MAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPP
PPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLP
QPPEHSTPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLL
PQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPP
PPHPSVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQQPPPPQGQQPP
HPPPGQQPPPPQPAKPQQVIQHHHSPRHHKSDPYSTGHLREAPSPLMIHSPQMSQFQSLT
HQSPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSEPFSPSLRPEPPKHPESI
KAPVHLPQRPEMKPVDVGRPVIRPPEQNAPPPGAPDKDKQKQEPKTPVAPKKDLKIKNMG
SWASLVQKHPTTPSSTAKSSSDSFEQFRRAAREKEEREKALKAQAEHAEKEKERLRQERM
RSREDEDALEQARRAHEEARRRQEQQQQQRQEQQQQQQQQAAAVAAAATPQAQSSQPQSM
LDQQRELARKREQERRRREAMAATIDMNFQSDLLSIFEENLF
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| BDBM50508328 |
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| n/a |
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| Name | BDBM50508328 |
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| Synonyms: | CHEMBL4514501 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H24N4O3S |
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| Mol. Mass. | 400.495 |
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| SMILES | Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)S(=O)(=O)NC1CCCC1 |
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| Structure | 
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