Ki Summary

Reaction Details

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Target

Muscarinic acetylcholine receptor M1

Ligand

BDBM50062593

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_138688 (CHEMBL749925)

IC50

28±n/a nM

Citation

Ward, JS; Merritt, L; Calligaro, DO; Bymaster, FP; Shannon, HE; Mitch, CH; Whitesitt, C; Brunsting, D; Sheardown, MJ; Olesen, PH; Swedberg, MD; Jeppesen, L; Sauerberg, P 1,2,5-Thiadiazole analogues of aceclidine as potent m1 muscarinic agonists. J Med Chem41:379-92 (1998) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Muscarinic acetylcholine receptor M1

Name:

Muscarinic acetylcholine receptor M1

Synonyms:

ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1

Type:

Enzyme Catalytic Domain

Mol. Mass.:

51390.46

Organism:

RAT

Description:

P08482

Residue:

460

Sequence:

MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC

BDBM50062593

n/a

Name

BDBM50062593

Synonyms:

3-(4-Hexylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-aza-bicyclo[2.2.2]octane | CHEMBL126237

Type

Small organic molecule

Emp. Form.

C15H25N3OS2

Mol. Mass.

327.508

SMILES

CCCCCCSc1nsnc1OC1CN2CCC1CC2 |(7.81,-17,;8.96,-15.97,;8.66,-14.47,;9.8,-13.45,;9.5,-11.93,;10.64,-10.9,;10.33,-9.4,;11.48,-8.38,;13,-8.7,;13.77,-7.35,;12.72,-6.2,;11.34,-6.83,;10,-6.06,;8.66,-6.83,;8.66,-8.38,;7.32,-9.14,;6.01,-8.38,;6.01,-6.83,;7.32,-6.05,;6.57,-7.39,;8.1,-7.79,)|

Structure