| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor ROR-gamma |
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| Ligand | BDBM50510353 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1841433 (CHEMBL4341732) |
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| Kd | 31±n/a nM |
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| Citation |  Tanis, VM; Venkatesan, H; Cummings, MD; Albers, M; Kent Barbay, J; Herman, K; Kummer, DA; Milligan, C; Nelen, MI; Nishimura, R; Schlueter, T; Scott, B; Spurlino, J; Wolin, R; Woods, C; Xue, X; Edwards, JP; Fourie, AM; Leonard, K 3-Substituted Quinolines as ROR?t Inverse Agonists. Bioorg Med Chem Lett29:1463-1470 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor ROR-gamma |
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| Name: | Nuclear receptor ROR-gamma |
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| Synonyms: | NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 58218.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51449 |
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| Residue: | 518 |
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| Sequence: | MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
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| BDBM50510353 |
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| n/a |
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| Name | BDBM50510353 |
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| Synonyms: | CHEMBL4589288 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H23ClN6O3S |
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| Mol. Mass. | 523.007 |
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| SMILES | COc1nc2ccc(cc2c(Cl)c1OCc1nccs1)C(O)(c1cnnn1C)c1ccc(C)nc1C |
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| Structure | 
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