Reaction Details |
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Target | Nuclear receptor ROR-gamma |
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Ligand | BDBM339137 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1841433 (CHEMBL4341732) |
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Kd | 14±n/a nM |
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Citation | Tanis, VM; Venkatesan, H; Cummings, MD; Albers, M; Kent Barbay, J; Herman, K; Kummer, DA; Milligan, C; Nelen, MI; Nishimura, R; Schlueter, T; Scott, B; Spurlino, J; Wolin, R; Woods, C; Xue, X; Edwards, JP; Fourie, AM; Leonard, K 3-Substituted Quinolines as ROR?t Inverse Agonists. Bioorg Med Chem Lett29:1463-1470 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Nuclear receptor ROR-gamma |
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Name: | Nuclear receptor ROR-gamma |
Synonyms: | NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 58218.40 |
Organism: | Homo sapiens (Human) |
Description: | P51449 |
Residue: | 518 |
Sequence: | MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
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BDBM339137 |
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n/a |
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Name | BDBM339137 |
Synonyms: | US10201546, Example 69a |
Type | Small organic molecule |
Emp. Form. | C26H28ClN5O4 |
Mol. Mass. | 509.985 |
SMILES | COc1nc2ccc(cc2c(Cl)c1OC1CCOCC1)C(O)(c1cnnn1C)c1ccc(C)nc1C |
Structure |
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