| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Stromelysin-1 |
|---|
| Ligand | BDBM50064796 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_104888 (CHEMBL709186) |
|---|
| IC50 | 3400±n/a nM |
|---|
| Citation |  Szardenings, AK; Harris, D; Lam, S; Shi, L; Tien, D; Wang, Y; Patel, DV; Navre, M; Campbell, DA Rational design and combinatorial evaluation of enzyme inhibitor scaffolds: identification of novel inhibitors of matrix metalloproteinases. J Med Chem41:2194-200 (1998) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Stromelysin-1 |
|---|
| Name: | Stromelysin-1 |
|---|
| Synonyms: | MMP-3 | MMP3 | MMP3_HUMAN | Matrix metalloproteinase (2 and 3) | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | STMY1 | Stromelysin 1 | Transin-1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 53973.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P08254 |
|---|
| Residue: | 477 |
|---|
| Sequence: | MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV
VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN
YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV
LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY
HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS
TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF
WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP
GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
|
|
|
|---|
| BDBM50064796 |
|---|
| n/a |
|---|
| Name | BDBM50064796 |
|---|
| Synonyms: | (3R,6S)-6-Butyl-1-cyclohexylmethyl-3-mercaptomethyl-piperazine-2,5-dione | CHEMBL305024 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H28N2O2S |
|---|
| Mol. Mass. | 312.471 |
|---|
| SMILES | CCCC[C@@H]1N(CC2CCCCC2)C(=O)[C@H](CS)NC1=O |
|---|
| Structure | 
|
|---|
Search and Browse
