Reaction Details |
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Target | Acid ceramidase |
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Ligand | BDBM50511263 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1844336 (CHEMBL4344763) |
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IC50 | 293±n/a nM |
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Citation | Di Martino, S; Tardia, P; Cilibrasi, V; Caputo, S; Mazzonna, M; Russo, D; Penna, I; Realini, N; Margaroli, N; Migliore, M; Pizzirani, D; Ottonello, G; Bertozzi, SM; Armirotti, A; Nguyen, D; Sun, Y; Bongarzone, ER; Lansbury, P; Liu, M; Skerlj, R; Scarpelli, R Lead Optimization of Benzoxazolone Carboxamides as Orally Bioavailable and CNS Penetrant Acid Ceramidase Inhibitors. J Med Chem63:3634-3664 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Acid ceramidase |
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Name: | Acid ceramidase |
Synonyms: | ASAH | ASAH1 | ASAH1_HUMAN | Acid ceramidase | Acid ceramidase (AC) |
Type: | Enzyme |
Mol. Mass.: | 44662.65 |
Organism: | Homo sapiens (Human) |
Description: | Q13510 |
Residue: | 395 |
Sequence: | MPGRSCVALVLLAAAVSCAVAQHAPPWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYK
RWHELMLDKAPVLKVIVNSLKNMINTFVPSGKIMQVVDEKLPGLLGNFPGPFEEEMKGIA
AVTDIPLGEIISFNIFYELFTICTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITE
QLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWI
LGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKE
SLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLST
KPVLNKLTVYTTLIDVTKGQFETYLRDCPDPCIGW
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BDBM50511263 |
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n/a |
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Name | BDBM50511263 |
Synonyms: | CHEMBL4448689 |
Type | Small organic molecule |
Emp. Form. | C19H23N3O4 |
Mol. Mass. | 357.4036 |
SMILES | CC(=O)N1CCc2oc(=O)n(C(=O)NCCCCc3ccccc3)c2C1 |
Structure |
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