| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta |
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| Ligand | BDBM50511414 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1844802 (CHEMBL4345229) |
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| IC50 | 6300±n/a nM |
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| Citation |  Manz, TD; Sivakumaren, SC; Yasgar, A; Hall, MD; Davis, MI; Seo, HS; Card, JD; Ficarro, SB; Shim, H; Marto, JA; Dhe-Paganon, S; Sasaki, AT; Boxer, MB; Simeonov, A; Cantley, LC; Shen, M; Zhang, T; Ferguson, FM; Gray, NS Structure-Activity Relationship Study of Covalent Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors. ACS Med Chem Lett11:346-352 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphatidylinositol 5-phosphate 4-kinase type-2 beta |
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| Name: | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta |
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| Synonyms: | PI42B_HUMAN | PIP4K2B | PIP5K2B | Phosphatidylinositol-5-phosphate 4-kinase type-2 beta |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47382.97 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774395 |
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| Residue: | 416 |
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| Sequence: | MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNV
PVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNS
VTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLL
PQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKD
NDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEE
RAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKK
EVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT
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| BDBM50511414 |
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| n/a |
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| Name | BDBM50511414 |
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| Synonyms: | CHEMBL4472811 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H33N7O2 |
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| Mol. Mass. | 583.6822 |
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| SMILES | CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2cc(Nc3ccc(cc3)-c3ccccc3)ncn2)c1 |
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| Structure | 
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