Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma
LigandBDBM50497347
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1844813 (CHEMBL4345240)
IC50 1000±n/a nM
Citation Manz, TD; Sivakumaren, SC; Yasgar, A; Hall, MD; Davis, MI; Seo, HS; Card, JD; Ficarro, SB; Shim, H; Marto, JA; Dhe-Paganon, S; Sasaki, AT; Boxer, MB; Simeonov, A; Cantley, LC; Shen, M; Zhang, T; Ferguson, FM; Gray, NS Structure-Activity Relationship Study of Covalent Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors. ACS Med Chem Lett11:346-352 (2020) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
Name:Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
Synonyms:PI(5)P 4-kinase type II gamma | PI42C_HUMAN | PIP4K2C | PIP4KII-gamma | PIP5K2C | Phosphatidylinositol-5-phosphate 4-kinase type II gamma | Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma
Type:PROTEIN
Mol. Mass.:47302.35
Organism:Homo sapiens (Human)
Description:ChEMBL_774614
Residue:421
Sequence:
MASSSVPPATVSAATAGPGPGFGFASKTKKKHFVQQKVKVFRAADPLVGVFLWGVAHSIN
ELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQ
DYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYIVKCHGNT
LLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTL
KDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEA
PVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAE
GAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAGAEISTVHPEQYAKRFLDFITNIF
A
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50497347
n/a
NameBDBM50497347
Synonyms:CHEMBL1529478
TypeSmall organic molecule
Emp. Form.C20H14F3N3S
Mol. Mass.385.405
SMILESFC(F)(F)c1ccccc1-c1nc(NCc2cccs2)c2ccccc2n1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: