Reaction Details |
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Target | Cathepsin K |
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Ligand | BDBM50066653 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_48326 (CHEMBL663316) |
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Ki | 30±n/a nM |
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Citation | Marquis, RW; Yamashita, DS; Ru, Y; LoCastro, SM; Oh, HJ; Erhard, KF; DesJarlais, RL; Head, MS; Smith, WW; Zhao, B; Janson, CA; Abdel-Meguid, SS; Tomaszek, TA; Levy, MA; Veber, DF Conformationally constrained 1,3-diamino ketones: a series of potent inhibitors of the cysteine protease cathepsin K. J Med Chem41:3563-7 (1998) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cathepsin K |
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Name: | Cathepsin K |
Synonyms: | CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X |
Type: | Enzyme |
Mol. Mass.: | 36975.68 |
Organism: | Homo sapiens (Human) |
Description: | P43235 |
Residue: | 329 |
Sequence: | MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
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BDBM50066653 |
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n/a |
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Name | BDBM50066653 |
Synonyms: | CHEMBL119219 | {(S)-3-Methyl-1-[4-oxo-1-(4-phenoxy-benzoyl)-pyrrolidin-3-ylcarbamoyl]-butyl}-carbamic acid benzyl ester |
Type | Small organic molecule |
Emp. Form. | C31H33N3O6 |
Mol. Mass. | 543.6102 |
SMILES | CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)NC1CN(CC1=O)C(=O)c1ccc(Oc2ccccc2)cc1 |
Structure |
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