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Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Protein Mdm4 | ||
| Ligand | BDBM50014089 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1852380 (CHEMBL4353004) | ||
| EC50 | 20000±n/a nM | ||
| Citation |  Liu, Y; Wang, X; Wang, G; Yang, Y; Yuan, Y; Ouyang, L The past, present and future of potential small-molecule drugs targeting p53-MDM2/MDMX for cancer therapy. Eur J Med Chem176:92-104 (2019) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Protein Mdm4 | |||
| Name: | Protein Mdm4 | ||
| Synonyms: | Double minute 4 protein | Double minute 4 protein (HDM4) | MDM2-MDMX | MDM4 | MDM4_HUMAN | MDMX | Mdm2-like p53-binding protein | Protein Mdm4 | Protein Mdmx | p53-Binding Protein HDMX | p53-binding protein | p53-binding protein Mdm4 | ||
| Type: | Oncoprotein | ||
| Mol. Mass.: | 54842.04 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | The HDMX(1-188) were expressed in Escherichia coli BL21 (DE3) as a GST fusion and purified on glutathione sepharose. | ||
| Residue: | 490 | ||
| Sequence: |
| ||
| BDBM50014089 | |||
| n/a | |||
| Name | BDBM50014089 | ||
| Synonyms: | CHEMBL1236726 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C35H38Cl2N6O | ||
| Mol. Mass. | 629.622 | ||
| SMILES | CN(C)CCCN(C)[C@H]1CCN(C1)C(=O)c1[nH]c2cc(Cl)ccc2c1-c1c(ncn1Cc1ccc(Cl)cc1)-c1ccccc1 |r,wD:8.7,(-5.37,10.95,;-4.13,10.05,;-2.72,10.67,;-4.29,8.51,;-3.04,7.61,;-3.2,6.08,;-1.96,5.17,;-.55,5.8,;-2.12,3.64,;-3.45,2.87,;-3.13,1.36,;-1.6,1.2,;-.97,2.61,;-.83,-.13,;-1.6,-1.46,;.71,-.13,;1.61,1.12,;3.08,.64,;4.41,1.41,;5.75,.64,;7.08,1.41,;5.75,-.9,;4.41,-1.67,;3.08,-.9,;1.61,-1.38,;1.14,-2.84,;2.04,-4.09,;1.14,-5.33,;-.33,-4.86,;-.33,-3.32,;-1.57,-2.41,;-2.98,-3.04,;-3.14,-4.57,;-4.55,-5.2,;-5.79,-4.29,;-7.2,-4.92,;-5.63,-2.76,;-4.23,-2.13,;3.58,-4.09,;4.35,-2.75,;5.89,-2.75,;6.66,-4.09,;5.89,-5.42,;4.35,-5.42,)| | ||
| Structure | 
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