| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Potassium channel subfamily K member 4 |
|---|
| Ligand | BDBM50514764 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1858319 (CHEMBL4359048) |
|---|
| EC50 | 15290±n/a nM |
|---|
| Citation |  Qiu, Y; Huang, L; Fu, J; Han, C; Fang, J; Liao, P; Chen, Z; Mo, Y; Sun, P; Liao, D; Yang, L; Wang, J; Zhang, Q; Liu, J; Liu, F; Liu, T; Huang, W; Yang, H; Jiang, R TREK Channel Family Activator with a Well-Defined Structure-Activation Relationship for Pain and Neurogenic Inflammation. J Med Chem63:3665-3677 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Potassium channel subfamily K member 4 |
|---|
| Name: | Potassium channel subfamily K member 4 |
|---|
| Synonyms: | KCNK4 | KCNK4_HUMAN | Potassium channel subfamily K member 4 | TRAAK |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 42711.88 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_116447 |
|---|
| Residue: | 393 |
|---|
| Sequence: | MRSTTLLALLALVLLYLVSGALVFRALEQPHEQQAQRELGEVREKFLRAHPCVSDQELGL
LIKEVADALGGGADPETNSTSNSSHSAWDLGSAFFFSGTIITTIGYGNVALRTDAGRLFC
IFYALVGIPLFGILLAGVGDRLGSSLRHGIGHIEAIFLKWHVPPELVRVLSAMLFLLIGC
LLFVLTPTFVFCYMEDWSKLEAIYFVIVTLTTVGFGDYVAGADPRQDSPAYQPLVWFWIL
LGLAYFASVLTTIGNWLRVVSRRTRAEMGGLTAQAASWTGTVTARVTQRAGPAAPPPEKE
QPLLPPPPCPAQPLGRPRSPSPPEKAQPPSPPTASALDYPSENLAFIDESSDTQSERGCP
LPRAPRGRRRPNPPRKPVRPRGPGRPRDKGVPV
|
|
|
|---|
| BDBM50514764 |
|---|
| n/a |
|---|
| Name | BDBM50514764 |
|---|
| Synonyms: | CHEMBL4552751 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H20N2O3S |
|---|
| Mol. Mass. | 380.46 |
|---|
| SMILES | Cc1ccc2nc(sc2c1)-c1ccc(NC(=O)[C@@H]2CC[C@@H](C2)C(O)=O)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
