| Reaction Details |
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 | Report a problem with these data |
| Target | Geranylgeranyl pyrophosphate synthase |
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| Ligand | BDBM50520637 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1881413 (CHEMBL4382912) |
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| IC50 | 75±n/a nM |
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| Citation |  Lacbay, CM; Waller, DD; Park, J; Gómez Palou, M; Vincent, F; Huang, XF; Ta, V; Berghuis, AM; Sebag, M; Tsantrizos, YS Unraveling the Prenylation-Cancer Paradox in Multiple Myeloma with Novel Geranylgeranyl Pyrophosphate Synthase (GGPPS) Inhibitors. J Med Chem61:6904-6917 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Geranylgeranyl pyrophosphate synthase |
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| Name: | Geranylgeranyl pyrophosphate synthase |
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| Synonyms: | Dimethylallyltranstransferase | Farnesyltranstransferase | GGPP synthetase | GGPPS_HUMAN | GGPPSase | GGPS1 | Geranylgeranyl Diphosphate Synthase (GGPPS) | Geranylgeranyl diphosphate synthase | Geranylgeranyl pyrophosphate synthetase | Geranyltranstransferase |
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| Type: | Homooctamer; transferase |
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| Mol. Mass.: | 34867.94 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human GGPPS was cloned and expressed in E. coli. |
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| Residue: | 300 |
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| Sequence: | MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS
LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL
ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL
GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN
IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
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| BDBM50520637 |
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| n/a |
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| Name | BDBM50520637 |
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| Synonyms: | CHEMBL4577077 | US11279719, Example I-37 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H19FN4O8P2S |
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| Mol. Mass. | 568.408 |
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| SMILES | COc1ccc(NC(=O)c2cccc(c2)-c2nc(NC(P(O)(O)=O)P(O)(O)=O)c3ccsc3n2)cc1F |
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| Structure | 
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