| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Geranylgeranyl pyrophosphate synthase |
|---|
| Ligand | BDBM50520638 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1881406 (CHEMBL4382905) |
|---|
| IC50 | 100±n/a nM |
|---|
| Citation |  Lacbay, CM; Waller, DD; Park, J; Gómez Palou, M; Vincent, F; Huang, XF; Ta, V; Berghuis, AM; Sebag, M; Tsantrizos, YS Unraveling the Prenylation-Cancer Paradox in Multiple Myeloma with Novel Geranylgeranyl Pyrophosphate Synthase (GGPPS) Inhibitors. J Med Chem61:6904-6917 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Geranylgeranyl pyrophosphate synthase |
|---|
| Name: | Geranylgeranyl pyrophosphate synthase |
|---|
| Synonyms: | Dimethylallyltranstransferase | Farnesyltranstransferase | GGPP synthetase | GGPPS_HUMAN | GGPPSase | GGPS1 | Geranylgeranyl Diphosphate Synthase (GGPPS) | Geranylgeranyl diphosphate synthase | Geranylgeranyl pyrophosphate synthetase | Geranyltranstransferase |
|---|
| Type: | Homooctamer; transferase |
|---|
| Mol. Mass.: | 34867.94 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Recombinant human GGPPS was cloned and expressed in E. coli. |
|---|
| Residue: | 300 |
|---|
| Sequence: | MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS
LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL
ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL
GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN
IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
|
|
|
|---|
| BDBM50520638 |
|---|
| n/a |
|---|
| Name | BDBM50520638 |
|---|
| Synonyms: | CHEMBL4471037 | US11279719, Example I-18 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H20N4O7P2S |
|---|
| Mol. Mass. | 534.419 |
|---|
| SMILES | Cc1ccc(cc1)C(=O)Nc1cccc(c1)-c1nc(NC(P(O)(O)=O)P(O)(O)=O)c2ccsc2n1 |
|---|
| Structure | 
|
|---|
Search and Browse
