Reaction Details |
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Target | Tyrosyl-DNA phosphodiesterase 2 |
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Ligand | BDBM50521699 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1884986 (CHEMBL4386568) |
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IC50 | 6.5±n/a nM |
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Citation | Kankanala, J; Ribeiro, CJA; Kiselev, E; Ravji, A; Williams, J; Xie, J; Aihara, H; Pommier, Y; Wang, Z Novel Deazaflavin Analogues Potently Inhibited Tyrosyl DNA Phosphodiesterase 2 (TDP2) and Strongly Sensitized Cancer Cells toward Treatment with Topoisomerase II (TOP2) Poison Etoposide. J Med Chem62:4669-4682 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosyl-DNA phosphodiesterase 2 |
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Name: | Tyrosyl-DNA phosphodiesterase 2 |
Synonyms: | EAP2 | EAPII | ETS1-associated protein 2 | ETS1-associated protein II | TDP2 | TRAF and TNF receptor-associated protein | TTRAP | TYDP2_HUMAN | Tyr-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 (hTDP2) | Tyrosyl-RNA phosphodiesterase | VPg unlinkase | hTDP2 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 40916.54 |
Organism: | Homo sapiens (Human) |
Description: | gi_23510348 |
Residue: | 362 |
Sequence: | MELGSCLEGGREAAEEEGEPEVKKRRLLCVEFASVASCDAAVAQCFLAENDWEMERALNS
YFEPPVEESALERRPETISEPKTYVDLTNEETTDSTTSKISPSEDTQQENGSMFSLITWN
IDGLDLNNLSERARGVCSYLALYSPDVIFLQEVIPPYYSYLKKRSSNYEIITGHEEGYFT
AIMLKKSRVKLKSQEIIPFPSTKMMRNLLCVHVNVSGNELCLMTSHLESTRGHAAERMNQ
LKMVLKKMQEAPESATVIFAGDTNLRDREVTRCGGLPNNIVDVWEFLGKPKHCQYTWDTQ
MNSNLGITAACKLRFDRIFFRAAAEEGHIIPRSLDLLGLEKLDCGRFPSDHWGLLCNLDI
IL
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BDBM50521699 |
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n/a |
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Name | BDBM50521699 |
Synonyms: | CHEMBL4572376 |
Type | Small organic molecule |
Emp. Form. | C25H16ClN5O4S |
Mol. Mass. | 517.944 |
SMILES | CS(=O)(=O)Nc1ccc(cc1)-n1c2cc(ccc2cc2c1nc(=O)n(-c1ccc(Cl)cc1)c2=O)C#N |
Structure |
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