| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cholinesterase |
|---|
| Ligand | BDBM50523373 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1890174 (CHEMBL4391928) |
|---|
| IC50 | 120±n/a nM |
|---|
| Citation |  Chalupova, K; Korabecny, J; Bartolini, M; Monti, B; Lamba, D; Caliandro, R; Pesaresi, A; Brazzolotto, X; Gastellier, AJ; Nachon, F; Pejchal, J; Jarosova, M; Hepnarova, V; Jun, D; Hrabinova, M; Dolezal, R; Zdarova Karasova, J; Mzik, M; Kristofikova, Z; Misik, J; Muckova, L; Jost, P; Soukup, O; Benkova, M; Setnicka, V; Habartova, L; Chvojkova, M; Kleteckova, L; Vales, K; Mezeiova, E; Uliassi, E; Valis, M; Nepovimova, E; Bolognesi, ML; Kuca, K Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease. Eur J Med Chem168:491-514 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cholinesterase |
|---|
| Name: | Cholinesterase |
|---|
| Synonyms: | Acylcholine acylhydrolase | BCHE | Butyrylcholine esterase (BChE) | Butyrylcholinesterase (BChE) | Butyrylcholinesterase (BuChE) | CHE1 | CHLE_HUMAN | Choline esterase II | Cholinesterases | Cholinesterases; ACHE & BCHE | Pseudocholinesterase |
|---|
| Type: | Homotetramer |
|---|
| Mol. Mass.: | 68422.27 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P06276 |
|---|
| Residue: | 602 |
|---|
| Sequence: | MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIP
YAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDC
LYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALG
FLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPG
SHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEI
LLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVY
GAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDV
VGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLER
RDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMT
KLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCV
GL
|
|
|
|---|
| BDBM50523373 |
|---|
| n/a |
|---|
| Name | BDBM50523373 |
|---|
| Synonyms: | CHEMBL4552440 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H34Cl3N5O |
|---|
| Mol. Mass. | 562.961 |
|---|
| SMILES | Cl.Cl.N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCCNc1c2CCCCc2nc2cc(Cl)ccc12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
