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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | RAC-alpha serine/threonine-protein kinase | ||
| Ligand | BDBM50528417 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1904982 (CHEMBL4407340) | ||
| IC50 | 2.9±n/a nM | ||
| Citation |  Dong, X; Zhan, W; Zhao, M; Che, J; Dai, X; Wu, Y; Xu, L; Zhou, Y; Zhao, Y; Tian, T; Cheng, G; Jin, Z; Li, J; Shao, Y; He, Q; Yang, B; Weng, Q; Hu, Y Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design. J Med Chem62:7264-7288 (2019) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| RAC-alpha serine/threonine-protein kinase | |||
| Name: | RAC-alpha serine/threonine-protein kinase | ||
| Synonyms: | AKT phosphorylation (p-AKT) | AKT1 | AKT1/PPP1CA | AKT1_HUMAN | C-AKT | PKB | PKB alpha | Protein kinase Akt-1 | Protein kinase B | Protein kinase B (AKT1) | Protein kinase B (Akt 1) | Protein kinase B (Akt) | Protein kinase B alpha | Protein kinase B alpha (AKT1) | Proto-oncogene Akt (Akt1) | Proto-oncogene c-Akt (AKT) | Proto-oncogene c-Akt (AKT1) | RAC | RAC-PK-alpha | RAC-alpha serine/threonine-protein kinase (AKT) | RAC-alpha serine/threonine-protein kinase (AKT1) | RAC-alpha serine/threonine-protein kinase (pAKT) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 55681.25 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P31749 | ||
| Residue: | 480 | ||
| Sequence: |
| ||
| BDBM50528417 | |||
| n/a | |||
| Name | BDBM50528417 | ||
| Synonyms: | CHEMBL4445510 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H18Cl4N4O2 | ||
| Mol. Mass. | 488.195 | ||
| SMILES | Cn1ncc(Cl)c1-c1cc(oc1Cl)C(=O)N[C@@H]1CNCC[C@H]1c1ccc(Cl)c(Cl)c1 |r,wU:16.17,wD:21.24,(6.56,-7.47,;6.24,-8.98,;4.83,-9.6,;4.99,-11.13,;6.49,-11.45,;7.12,-12.86,;7.27,-10.12,;8.8,-9.97,;9.83,-11.12,;11.23,-10.49,;11.08,-8.96,;9.57,-8.64,;8.95,-7.23,;12.56,-11.27,;12.56,-12.81,;13.9,-10.5,;15.23,-11.27,;15.23,-12.81,;16.56,-13.59,;17.89,-12.82,;17.9,-11.27,;16.57,-10.51,;16.57,-8.97,;15.24,-8.2,;15.24,-6.66,;16.57,-5.89,;16.57,-4.35,;17.91,-6.65,;19.24,-5.88,;17.91,-8.2,)| | ||
| Structure | 
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