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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | RAC-alpha serine/threonine-protein kinase | ||
| Ligand | BDBM50528426 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1904982 (CHEMBL4407340) | ||
| IC50 | 2.5±n/a nM | ||
| Citation |  Dong, X; Zhan, W; Zhao, M; Che, J; Dai, X; Wu, Y; Xu, L; Zhou, Y; Zhao, Y; Tian, T; Cheng, G; Jin, Z; Li, J; Shao, Y; He, Q; Yang, B; Weng, Q; Hu, Y Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design. J Med Chem62:7264-7288 (2019) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| RAC-alpha serine/threonine-protein kinase | |||
| Name: | RAC-alpha serine/threonine-protein kinase | ||
| Synonyms: | AKT phosphorylation (p-AKT) | AKT1 | AKT1/PPP1CA | AKT1_HUMAN | C-AKT | PKB | PKB alpha | Protein kinase Akt-1 | Protein kinase B | Protein kinase B (AKT1) | Protein kinase B (Akt 1) | Protein kinase B (Akt) | Protein kinase B alpha | Protein kinase B alpha (AKT1) | Proto-oncogene Akt (Akt1) | Proto-oncogene c-Akt (AKT) | Proto-oncogene c-Akt (AKT1) | RAC | RAC-PK-alpha | RAC-alpha serine/threonine-protein kinase (AKT) | RAC-alpha serine/threonine-protein kinase (AKT1) | RAC-alpha serine/threonine-protein kinase (pAKT) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 55681.25 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P31749 | ||
| Residue: | 480 | ||
| Sequence: |
| ||
| BDBM50528426 | |||
| n/a | |||
| Name | BDBM50528426 | ||
| Synonyms: | CHEMBL4460525 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H25Cl2F2N5O3 | ||
| Mol. Mass. | 540.39 | ||
| SMILES | CC(=O)NCC[C@@H]1C[C@H]([C@@H](CN1)NC(=O)c1cc(c(Cl)o1)-c1c(Cl)cnn1C)c1ccc(F)c(F)c1 |r,wU:9.12,6.5,wD:8.30,(53.86,-29.77,;52.53,-29,;52.54,-27.46,;51.2,-29.76,;49.87,-28.99,;48.53,-29.75,;47.2,-28.98,;47.21,-27.43,;45.87,-26.67,;44.54,-27.43,;44.53,-28.97,;45.86,-29.74,;43.2,-26.66,;41.87,-27.43,;41.86,-28.97,;40.54,-26.65,;39.12,-27.27,;38.09,-26.13,;38.87,-24.8,;38.25,-23.39,;40.37,-25.12,;36.56,-26.29,;35.79,-27.62,;36.41,-29.03,;34.28,-27.3,;34.12,-25.76,;35.53,-25.14,;35.86,-23.64,;45.87,-25.13,;44.54,-24.36,;44.54,-22.82,;45.87,-22.05,;45.86,-20.51,;47.2,-22.81,;48.54,-22.04,;47.21,-24.36,)| | ||
| Structure | 
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