Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | RAC-alpha serine/threonine-protein kinase | ||
| Ligand | BDBM50528434 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1904982 (CHEMBL4407340) | ||
| IC50 | 6.4±n/a nM | ||
| Citation |  Dong, X; Zhan, W; Zhao, M; Che, J; Dai, X; Wu, Y; Xu, L; Zhou, Y; Zhao, Y; Tian, T; Cheng, G; Jin, Z; Li, J; Shao, Y; He, Q; Yang, B; Weng, Q; Hu, Y Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design. J Med Chem62:7264-7288 (2019) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| RAC-alpha serine/threonine-protein kinase | |||
| Name: | RAC-alpha serine/threonine-protein kinase | ||
| Synonyms: | AKT phosphorylation (p-AKT) | AKT1 | AKT1/PPP1CA | AKT1_HUMAN | C-AKT | PKB | PKB alpha | Protein kinase Akt-1 | Protein kinase B | Protein kinase B (AKT1) | Protein kinase B (Akt 1) | Protein kinase B (Akt) | Protein kinase B alpha | Protein kinase B alpha (AKT1) | Proto-oncogene Akt (Akt1) | Proto-oncogene c-Akt (AKT) | Proto-oncogene c-Akt (AKT1) | RAC | RAC-PK-alpha | RAC-alpha serine/threonine-protein kinase (AKT) | RAC-alpha serine/threonine-protein kinase (AKT1) | RAC-alpha serine/threonine-protein kinase (pAKT) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 55681.25 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P31749 | ||
| Residue: | 480 | ||
| Sequence: |
| ||
| BDBM50528434 | |||
| n/a | |||
| Name | BDBM50528434 | ||
| Synonyms: | CHEMBL4546392 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H29Cl4N5O2 | ||
| Mol. Mass. | 585.353 | ||
| SMILES | Cn1ncc(Cl)c1-c1cc(oc1Cl)C(=O)N[C@@H]1CN[C@H](CCN2CCCC2)C[C@H]1c1ccc(Cl)c(Cl)c1 |r,wU:16.17,19.21,wD:28.32,(7.84,-37.33,;7.52,-38.84,;6.11,-39.46,;6.26,-40.99,;7.77,-41.32,;8.39,-42.72,;8.54,-39.98,;10.08,-39.82,;11.11,-40.97,;12.52,-40.35,;12.36,-38.82,;10.85,-38.49,;10.23,-37.08,;13.85,-41.12,;13.85,-42.66,;15.19,-40.36,;16.52,-41.13,;16.52,-42.66,;17.85,-43.44,;19.18,-42.67,;20.51,-43.45,;21.85,-42.68,;23.18,-43.46,;23.34,-44.98,;24.85,-45.31,;25.62,-43.98,;24.59,-42.83,;19.19,-41.13,;17.86,-40.36,;17.86,-38.83,;16.52,-38.06,;16.52,-36.52,;17.85,-35.75,;17.85,-34.21,;19.19,-36.51,;20.52,-35.73,;19.19,-38.06,)| | ||
| Structure | 
| ||