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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | RAC-alpha serine/threonine-protein kinase | ||
| Ligand | BDBM50528453 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1904982 (CHEMBL4407340) | ||
| IC50 | 17±n/a nM | ||
| Citation |  Dong, X; Zhan, W; Zhao, M; Che, J; Dai, X; Wu, Y; Xu, L; Zhou, Y; Zhao, Y; Tian, T; Cheng, G; Jin, Z; Li, J; Shao, Y; He, Q; Yang, B; Weng, Q; Hu, Y Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design. J Med Chem62:7264-7288 (2019) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| RAC-alpha serine/threonine-protein kinase | |||
| Name: | RAC-alpha serine/threonine-protein kinase | ||
| Synonyms: | AKT phosphorylation (p-AKT) | AKT1 | AKT1/PPP1CA | AKT1_HUMAN | C-AKT | PKB | PKB alpha | Protein kinase Akt-1 | Protein kinase B | Protein kinase B (AKT1) | Protein kinase B (Akt 1) | Protein kinase B (Akt) | Protein kinase B alpha | Protein kinase B alpha (AKT1) | Proto-oncogene Akt (Akt1) | Proto-oncogene c-Akt (AKT) | Proto-oncogene c-Akt (AKT1) | RAC | RAC-PK-alpha | RAC-alpha serine/threonine-protein kinase (AKT) | RAC-alpha serine/threonine-protein kinase (AKT1) | RAC-alpha serine/threonine-protein kinase (pAKT) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 55681.25 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P31749 | ||
| Residue: | 480 | ||
| Sequence: |
| ||
| BDBM50528453 | |||
| n/a | |||
| Name | BDBM50528453 | ||
| Synonyms: | CHEMBL4554683 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H19Cl3N4O2 | ||
| Mol. Mass. | 453.749 | ||
| SMILES | Cn1ncc(Cl)c1-c1cc(oc1Cl)C(=O)N[C@@H]1CNCC[C@H]1c1ccc(Cl)cc1 |r,wU:16.17,wD:21.24,(47.52,-7.99,;47.2,-9.5,;45.79,-10.12,;45.95,-11.65,;47.45,-11.98,;48.07,-13.38,;48.22,-10.64,;49.76,-10.49,;50.79,-11.64,;52.19,-11.02,;52.04,-9.48,;50.53,-9.16,;49.91,-7.75,;53.52,-11.79,;53.52,-13.33,;54.86,-11.02,;56.19,-11.8,;56.18,-13.33,;57.51,-14.11,;58.85,-13.34,;58.86,-11.79,;57.52,-11.03,;57.53,-9.49,;56.2,-8.72,;56.2,-7.18,;57.53,-6.41,;57.52,-4.87,;58.86,-7.17,;58.87,-8.72,)| | ||
| Structure | 
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