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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | RAC-alpha serine/threonine-protein kinase | ||
| Ligand | BDBM50528458 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1904982 (CHEMBL4407340) | ||
| IC50 | 6.4±n/a nM | ||
| Citation |  Dong, X; Zhan, W; Zhao, M; Che, J; Dai, X; Wu, Y; Xu, L; Zhou, Y; Zhao, Y; Tian, T; Cheng, G; Jin, Z; Li, J; Shao, Y; He, Q; Yang, B; Weng, Q; Hu, Y Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design. J Med Chem62:7264-7288 (2019) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| RAC-alpha serine/threonine-protein kinase | |||
| Name: | RAC-alpha serine/threonine-protein kinase | ||
| Synonyms: | AKT phosphorylation (p-AKT) | AKT1 | AKT1/PPP1CA | AKT1_HUMAN | C-AKT | PKB | PKB alpha | Protein kinase Akt-1 | Protein kinase B | Protein kinase B (AKT1) | Protein kinase B (Akt 1) | Protein kinase B (Akt) | Protein kinase B alpha | Protein kinase B alpha (AKT1) | Proto-oncogene Akt (Akt1) | Proto-oncogene c-Akt (AKT) | Proto-oncogene c-Akt (AKT1) | RAC | RAC-PK-alpha | RAC-alpha serine/threonine-protein kinase (AKT) | RAC-alpha serine/threonine-protein kinase (AKT1) | RAC-alpha serine/threonine-protein kinase (pAKT) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 55681.25 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P31749 | ||
| Residue: | 480 | ||
| Sequence: |
| ||
| BDBM50528458 | |||
| n/a | |||
| Name | BDBM50528458 | ||
| Synonyms: | CHEMBL4465572 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H24Cl2F2N4O8 | ||
| Mol. Mass. | 605.372 | ||
| SMILES | O[C@H]([C@@H](O)C(O)=O)C(O)=O.Cn1ncc(Cl)c1-c1cc(oc1Cl)C(=O)NC1CNCCC1c1ccc(F)c(F)c1 |r,wD:1.0,2.2,(45.48,-28.24,;45.48,-26.7,;44.14,-25.93,;44.14,-24.39,;42.8,-26.7,;41.47,-25.93,;42.8,-28.24,;46.81,-25.93,;48.14,-26.7,;46.81,-24.39,;28.5,-19.99,;28.18,-21.5,;26.77,-22.12,;26.93,-23.65,;28.43,-23.98,;29.05,-25.38,;29.21,-22.64,;30.74,-22.49,;31.77,-23.64,;33.17,-23.01,;33.02,-21.48,;31.51,-21.16,;30.89,-19.75,;34.5,-23.79,;34.5,-25.33,;35.84,-23.02,;37.17,-23.8,;37.16,-25.33,;38.49,-26.11,;39.83,-25.34,;39.84,-23.79,;38.51,-23.03,;38.51,-21.49,;37.18,-20.72,;37.18,-19.18,;38.51,-18.41,;38.5,-16.87,;39.84,-19.17,;41.17,-18.4,;39.85,-20.72,)| | ||
| Structure | 
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