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TargetRAC-alpha serine/threonine-protein kinase
LigandBDBM50528468
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1904982 (CHEMBL4407340)
IC50 3.4±n/a nM
Citation Dong, XZhan, WZhao, MChe, JDai, XWu, YXu, LZhou, YZhao, YTian, TCheng, GJin, ZLi, JShao, YHe, QYang, BWeng, QHu, Y Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design. J Med Chem62:7264-7288 (2019) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
RAC-alpha serine/threonine-protein kinase
Name:RAC-alpha serine/threonine-protein kinase
Synonyms:AKT phosphorylation (p-AKT) | AKT1 | AKT1/PPP1CA | AKT1_HUMAN | C-AKT | PKB | PKB alpha | Protein kinase Akt-1 | Protein kinase B | Protein kinase B (AKT1) | Protein kinase B (Akt 1) | Protein kinase B (Akt) | Protein kinase B alpha | Protein kinase B alpha (AKT1) | Proto-oncogene Akt (Akt1) | Proto-oncogene c-Akt (AKT) | Proto-oncogene c-Akt (AKT1) | RAC | RAC-PK-alpha | RAC-alpha serine/threonine-protein kinase (AKT) | RAC-alpha serine/threonine-protein kinase (AKT1) | RAC-alpha serine/threonine-protein kinase (pAKT)
Type:Enzyme
Mol. Mass.:55681.25
Organism:Homo sapiens (Human)
Description:P31749
Residue:480
Sequence:
MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC
QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF
RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI
KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK
LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50528468
n/a
NameBDBM50528468
Synonyms:CHEMBL4590906
TypeSmall organic molecule
Emp. Form.C24H27Cl4N5O2
Mol. Mass.559.315
SMILESCN(C)CC[C@@H]1C[C@H]([C@@H](CN1)NC(=O)c1cc(c(Cl)o1)-c1c(Cl)cnn1C)c1ccc(Cl)c(Cl)c1 |r,wU:8.11,5.4,wD:7.29,(76.96,-26.16,;75.63,-26.92,;75.62,-28.46,;74.3,-26.15,;72.96,-26.91,;71.63,-26.14,;71.64,-24.59,;70.3,-23.83,;68.97,-24.59,;68.96,-26.13,;70.29,-26.9,;67.63,-23.82,;66.3,-24.59,;66.29,-26.13,;64.97,-23.81,;63.55,-24.44,;62.52,-23.29,;63.3,-21.96,;62.67,-20.55,;64.8,-22.28,;60.99,-23.45,;60.21,-24.78,;60.84,-26.19,;58.71,-24.46,;58.55,-22.92,;59.96,-22.3,;60.28,-20.8,;70.3,-22.3,;68.97,-21.53,;68.97,-19.98,;70.3,-19.21,;70.29,-17.67,;71.63,-19.97,;72.96,-19.2,;71.64,-21.52,)|
Structure
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