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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | RAC-alpha serine/threonine-protein kinase | ||
| Ligand | BDBM50528469 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1904982 (CHEMBL4407340) | ||
| IC50 | 10±n/a nM | ||
| Citation |  Dong, X; Zhan, W; Zhao, M; Che, J; Dai, X; Wu, Y; Xu, L; Zhou, Y; Zhao, Y; Tian, T; Cheng, G; Jin, Z; Li, J; Shao, Y; He, Q; Yang, B; Weng, Q; Hu, Y Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design. J Med Chem62:7264-7288 (2019) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| RAC-alpha serine/threonine-protein kinase | |||
| Name: | RAC-alpha serine/threonine-protein kinase | ||
| Synonyms: | AKT phosphorylation (p-AKT) | AKT1 | AKT1/PPP1CA | AKT1_HUMAN | C-AKT | PKB | PKB alpha | Protein kinase Akt-1 | Protein kinase B | Protein kinase B (AKT1) | Protein kinase B (Akt 1) | Protein kinase B (Akt) | Protein kinase B alpha | Protein kinase B alpha (AKT1) | Proto-oncogene Akt (Akt1) | Proto-oncogene c-Akt (AKT) | Proto-oncogene c-Akt (AKT1) | RAC | RAC-PK-alpha | RAC-alpha serine/threonine-protein kinase (AKT) | RAC-alpha serine/threonine-protein kinase (AKT1) | RAC-alpha serine/threonine-protein kinase (pAKT) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 55681.25 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P31749 | ||
| Residue: | 480 | ||
| Sequence: |
| ||
| BDBM50528469 | |||
| n/a | |||
| Name | BDBM50528469 | ||
| Synonyms: | CHEMBL4467439 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H24Cl4N4O2 | ||
| Mol. Mass. | 530.274 | ||
| SMILES | CCC[C@@H]1C[C@H]([C@@H](CN1)NC(=O)c1cc(c(Cl)o1)-c1c(Cl)cnn1C)c1ccc(Cl)c(Cl)c1 |r,wU:6.9,3.2,wD:5.27,(21.58,-13.12,;20.25,-12.34,;18.91,-13.11,;17.58,-12.33,;17.59,-10.79,;16.26,-10.02,;14.92,-10.79,;14.91,-12.32,;16.24,-13.1,;13.59,-10.02,;12.25,-10.78,;12.25,-12.32,;10.92,-10.01,;9.5,-10.63,;8.48,-9.48,;9.25,-8.15,;8.63,-6.74,;10.76,-8.48,;6.94,-9.64,;6.17,-10.97,;6.79,-12.38,;4.66,-10.65,;4.51,-9.12,;5.91,-8.5,;6.24,-6.99,;16.25,-8.49,;14.92,-7.72,;14.92,-6.18,;16.25,-5.4,;16.25,-3.86,;17.59,-6.17,;18.92,-5.39,;17.59,-7.72,)| | ||
| Structure | 
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