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TargetRAC-alpha serine/threonine-protein kinase
LigandBDBM50528469
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1904982 (CHEMBL4407340)
IC50 10±n/a nM
Citation Dong, XZhan, WZhao, MChe, JDai, XWu, YXu, LZhou, YZhao, YTian, TCheng, GJin, ZLi, JShao, YHe, QYang, BWeng, QHu, Y Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design. J Med Chem62:7264-7288 (2019) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
RAC-alpha serine/threonine-protein kinase
Name:RAC-alpha serine/threonine-protein kinase
Synonyms:AKT phosphorylation (p-AKT) | AKT1 | AKT1/PPP1CA | AKT1_HUMAN | C-AKT | PKB | PKB alpha | Protein kinase Akt-1 | Protein kinase B | Protein kinase B (AKT1) | Protein kinase B (Akt 1) | Protein kinase B (Akt) | Protein kinase B alpha | Protein kinase B alpha (AKT1) | Proto-oncogene Akt (Akt1) | Proto-oncogene c-Akt (AKT) | Proto-oncogene c-Akt (AKT1) | RAC | RAC-PK-alpha | RAC-alpha serine/threonine-protein kinase (AKT) | RAC-alpha serine/threonine-protein kinase (AKT1) | RAC-alpha serine/threonine-protein kinase (pAKT)
Type:Enzyme
Mol. Mass.:55681.25
Organism:Homo sapiens (Human)
Description:P31749
Residue:480
Sequence:
MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC
QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF
RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI
KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK
LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
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  Blast E-value cutoff:
BDBM50528469
n/a
NameBDBM50528469
Synonyms:CHEMBL4467439
TypeSmall organic molecule
Emp. Form.C23H24Cl4N4O2
Mol. Mass.530.274
SMILESCCC[C@@H]1C[C@H]([C@@H](CN1)NC(=O)c1cc(c(Cl)o1)-c1c(Cl)cnn1C)c1ccc(Cl)c(Cl)c1 |r,wU:6.9,3.2,wD:5.27,(21.58,-13.12,;20.25,-12.34,;18.91,-13.11,;17.58,-12.33,;17.59,-10.79,;16.26,-10.02,;14.92,-10.79,;14.91,-12.32,;16.24,-13.1,;13.59,-10.02,;12.25,-10.78,;12.25,-12.32,;10.92,-10.01,;9.5,-10.63,;8.48,-9.48,;9.25,-8.15,;8.63,-6.74,;10.76,-8.48,;6.94,-9.64,;6.17,-10.97,;6.79,-12.38,;4.66,-10.65,;4.51,-9.12,;5.91,-8.5,;6.24,-6.99,;16.25,-8.49,;14.92,-7.72,;14.92,-6.18,;16.25,-5.4,;16.25,-3.86,;17.59,-6.17,;18.92,-5.39,;17.59,-7.72,)|
Structure
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