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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | RAC-alpha serine/threonine-protein kinase | ||
| Ligand | BDBM50528479 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1904982 (CHEMBL4407340) | ||
| IC50 | 8.8±n/a nM | ||
| Citation |  Dong, X; Zhan, W; Zhao, M; Che, J; Dai, X; Wu, Y; Xu, L; Zhou, Y; Zhao, Y; Tian, T; Cheng, G; Jin, Z; Li, J; Shao, Y; He, Q; Yang, B; Weng, Q; Hu, Y Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design. J Med Chem62:7264-7288 (2019) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| RAC-alpha serine/threonine-protein kinase | |||
| Name: | RAC-alpha serine/threonine-protein kinase | ||
| Synonyms: | AKT phosphorylation (p-AKT) | AKT1 | AKT1/PPP1CA | AKT1_HUMAN | C-AKT | PKB | PKB alpha | Protein kinase Akt-1 | Protein kinase B | Protein kinase B (AKT1) | Protein kinase B (Akt 1) | Protein kinase B (Akt) | Protein kinase B alpha | Protein kinase B alpha (AKT1) | Proto-oncogene Akt (Akt1) | Proto-oncogene c-Akt (AKT) | Proto-oncogene c-Akt (AKT1) | RAC | RAC-PK-alpha | RAC-alpha serine/threonine-protein kinase (AKT) | RAC-alpha serine/threonine-protein kinase (AKT1) | RAC-alpha serine/threonine-protein kinase (pAKT) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 55681.25 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P31749 | ||
| Residue: | 480 | ||
| Sequence: |
| ||
| BDBM50528479 | |||
| n/a | |||
| Name | BDBM50528479 | ||
| Synonyms: | CHEMBL4450403 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H29Cl4N5O3 | ||
| Mol. Mass. | 601.352 | ||
| SMILES | Cn1ncc(Cl)c1-c1cc(oc1Cl)C(=O)N[C@@H]1CN[C@H](CCN2CCOCC2)C[C@H]1c1ccc(Cl)c(Cl)c1 |r,wU:16.17,19.21,wD:29.33,(61.2,-37.04,;60.88,-38.54,;59.47,-39.16,;59.63,-40.7,;61.13,-41.02,;61.76,-42.43,;61.91,-39.69,;63.44,-39.53,;64.47,-40.68,;65.88,-40.05,;65.72,-38.52,;64.22,-38.2,;63.59,-36.79,;67.22,-40.83,;67.21,-42.37,;68.55,-40.06,;69.88,-40.83,;69.88,-42.37,;71.21,-43.14,;72.55,-42.38,;73.88,-43.15,;75.21,-42.39,;76.54,-43.16,;76.53,-44.7,;77.85,-45.47,;79.19,-44.72,;79.2,-43.17,;77.87,-42.39,;72.55,-40.83,;71.22,-40.07,;71.22,-38.54,;69.89,-37.77,;69.89,-36.22,;71.22,-35.45,;71.21,-33.91,;72.55,-36.21,;73.88,-35.44,;72.56,-37.76,)| | ||
| Structure | 
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