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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | RAC-alpha serine/threonine-protein kinase | ||
| Ligand | BDBM50528481 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1904982 (CHEMBL4407340) | ||
| IC50 | 17±n/a nM | ||
| Citation |  Dong, X; Zhan, W; Zhao, M; Che, J; Dai, X; Wu, Y; Xu, L; Zhou, Y; Zhao, Y; Tian, T; Cheng, G; Jin, Z; Li, J; Shao, Y; He, Q; Yang, B; Weng, Q; Hu, Y Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design. J Med Chem62:7264-7288 (2019) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| RAC-alpha serine/threonine-protein kinase | |||
| Name: | RAC-alpha serine/threonine-protein kinase | ||
| Synonyms: | AKT phosphorylation (p-AKT) | AKT1 | AKT1/PPP1CA | AKT1_HUMAN | C-AKT | PKB | PKB alpha | Protein kinase Akt-1 | Protein kinase B | Protein kinase B (AKT1) | Protein kinase B (Akt 1) | Protein kinase B (Akt) | Protein kinase B alpha | Protein kinase B alpha (AKT1) | Proto-oncogene Akt (Akt1) | Proto-oncogene c-Akt (AKT) | Proto-oncogene c-Akt (AKT1) | RAC | RAC-PK-alpha | RAC-alpha serine/threonine-protein kinase (AKT) | RAC-alpha serine/threonine-protein kinase (AKT1) | RAC-alpha serine/threonine-protein kinase (pAKT) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 55681.25 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P31749 | ||
| Residue: | 480 | ||
| Sequence: |
| ||
| BDBM50528481 | |||
| n/a | |||
| Name | BDBM50528481 | ||
| Synonyms: | CHEMBL4443488 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H25Cl3N4O8 | ||
| Mol. Mass. | 603.836 | ||
| SMILES | O[C@H]([C@@H](O)C(O)=O)C(O)=O.Cn1ncc(Cl)c1-c1cc(oc1Cl)C(=O)NC1CNCCC1c1ccc(Cl)cc1 |r,wD:1.0,2.2,(86.62,-13.81,;86.62,-12.27,;85.28,-11.5,;85.28,-9.96,;83.95,-12.27,;82.62,-11.5,;83.95,-13.81,;87.95,-11.5,;89.29,-12.27,;87.95,-9.96,;70.57,-5.57,;70.24,-7.08,;68.83,-7.7,;68.99,-9.23,;70.5,-9.56,;71.12,-10.97,;71.27,-8.23,;72.8,-8.07,;73.83,-9.22,;75.23,-8.6,;75.08,-7.06,;73.58,-6.74,;72.95,-5.33,;76.56,-9.37,;76.56,-10.91,;77.9,-8.6,;79.23,-9.38,;79.23,-10.91,;80.56,-11.69,;81.9,-10.92,;81.9,-9.38,;80.57,-8.61,;80.58,-7.07,;79.24,-6.3,;79.24,-4.76,;80.57,-3.99,;80.57,-2.45,;81.91,-4.75,;81.91,-6.3,)| | ||
| Structure | 
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