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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | RAC-alpha serine/threonine-protein kinase | ||
| Ligand | BDBM50528482 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1904982 (CHEMBL4407340) | ||
| IC50 | 3.1±n/a nM | ||
| Citation |  Dong, X; Zhan, W; Zhao, M; Che, J; Dai, X; Wu, Y; Xu, L; Zhou, Y; Zhao, Y; Tian, T; Cheng, G; Jin, Z; Li, J; Shao, Y; He, Q; Yang, B; Weng, Q; Hu, Y Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design. J Med Chem62:7264-7288 (2019) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| RAC-alpha serine/threonine-protein kinase | |||
| Name: | RAC-alpha serine/threonine-protein kinase | ||
| Synonyms: | AKT phosphorylation (p-AKT) | AKT1 | AKT1/PPP1CA | AKT1_HUMAN | C-AKT | PKB | PKB alpha | Protein kinase Akt-1 | Protein kinase B | Protein kinase B (AKT1) | Protein kinase B (Akt 1) | Protein kinase B (Akt) | Protein kinase B alpha | Protein kinase B alpha (AKT1) | Proto-oncogene Akt (Akt1) | Proto-oncogene c-Akt (AKT) | Proto-oncogene c-Akt (AKT1) | RAC | RAC-PK-alpha | RAC-alpha serine/threonine-protein kinase (AKT) | RAC-alpha serine/threonine-protein kinase (AKT1) | RAC-alpha serine/threonine-protein kinase (pAKT) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 55681.25 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P31749 | ||
| Residue: | 480 | ||
| Sequence: |
| ||
| BDBM50528482 | |||
| n/a | |||
| Name | BDBM50528482 | ||
| Synonyms: | CHEMBL4593086 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H27Cl4N5O5 | ||
| Mol. Mass. | 619.324 | ||
| SMILES | Cn1ncc(Cl)c1-c1cc(oc1Cl)C(=O)N[C@@H]1CN[C@H](CC(=O)NCC(O)CO)C[C@H]1c1ccc(Cl)c(Cl)c1 |r,wU:16.17,19.21,wD:30.33,(62.66,-40.72,;62.33,-42.23,;60.93,-42.85,;61.08,-44.38,;62.59,-44.71,;63.21,-46.12,;63.36,-43.38,;64.9,-43.22,;65.92,-44.36,;67.34,-43.74,;67.18,-42.21,;65.67,-41.88,;65.05,-40.48,;68.67,-44.51,;68.67,-46.05,;70.01,-43.75,;71.34,-44.52,;71.33,-46.05,;72.66,-46.83,;74,-46.06,;75.33,-46.84,;76.67,-46.07,;76.67,-44.53,;78,-46.85,;79.34,-46.08,;80.67,-46.86,;80.66,-48.4,;82,-46.09,;83.33,-46.87,;74.01,-44.52,;72.68,-43.75,;72.67,-42.22,;71.34,-41.45,;71.34,-39.91,;72.67,-39.14,;72.67,-37.6,;74.01,-39.9,;75.34,-39.13,;74.01,-41.45,)| | ||
| Structure | 
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