| Reaction Details |
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 | Report a problem with these data |
| Target | Short transient receptor potential channel 5 |
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| Ligand | BDBM50529422 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1908676 (CHEMBL4411034) |
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| IC50 | 7800±n/a nM |
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| Citation |  Yu, M; Ledeboer, MW; Daniels, M; Malojcic, G; Tibbitts, TT; Coeffet-Le Gal, M; Pan-Zhou, XR; Westerling-Bui, A; Beconi, M; Reilly, JF; Mundel, P; Harmange, JC Discovery of a Potent and Selective TRPC5 Inhibitor, Efficacious in a Focal Segmental Glomerulosclerosis Model. ACS Med Chem Lett10:1579-1585 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Short transient receptor potential channel 5 |
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| Name: | Short transient receptor potential channel 5 |
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| Synonyms: | TRP5 | TRPC5 | TRPC5_HUMAN | Transient receptor protein 5 (TRPC5) |
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| Type: | Enzyme |
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| Mol. Mass.: | 111421.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9UL62 |
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| Residue: | 973 |
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| Sequence: | MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYN
VNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRR
PSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVE
CVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAE
YEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKE
FVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFI
KKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIK
EMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEA
LFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYF
YYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFV
GATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPP
FNIIPSPKSFLYLGNWFNNTFCPKRDPDGRRRRRNLRSFTERNADSLIQNQHYQEVIRNL
VKRYVAAMIRNSKTHEGLTEENFKELKQDISSFRYEVLDLLGNRKHPRSFSTSSTELSQR
DDNNDGSGGARAKSKSVSFNLGCKKKTCHGPPLIRTMPRSSGAQGKSKAESSSKRSFMGP
SLKKLGLLFSKFNGHMSEPSSEPMYTISDGIVQQHCMWQDIRYSQMEKGKAEACSQSEIN
LSEVELGEVQGAAQSSECPLACSSSLHCASSICSSNSKLLDSSEDVFETWGEACDLLMHK
WGDGQEEQVTTRL
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| BDBM50529422 |
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| n/a |
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| Name | BDBM50529422 |
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| Synonyms: | CHEMBL4447753 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H19BrN4O |
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| Mol. Mass. | 363.252 |
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| SMILES | Cc1ccccc1CN1CCN(CC1)c1cn[nH]c(=O)c1Br |
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| Structure | 
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