Reaction Details |
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Target | Cytochrome P450 2D6 |
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Ligand | BDBM50529952 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1910984 (CHEMBL4413430) |
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IC50 | 1300±n/a nM |
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Citation | Saccoliti, F; Madia, VN; Tudino, V; De Leo, A; Pescatori, L; Messore, A; De Vita, D; Scipione, L; Brun, R; Kaiser, M; Mäser, P; Calvet, CM; Jennings, GK; Podust, LM; Pepe, G; Cirilli, R; Faggi, C; Di Marco, A; Battista, MR; Summa, V; Costi, R; Di Santo, R Design, Synthesis, and Biological Evaluation of New 1-(Aryl-1 H-pyrrolyl)(phenyl)methyl-1 H-imidazole Derivatives as Antiprotozoal Agents. J Med Chem62:1330-1347 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 2D6 |
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Name: | Cytochrome P450 2D6 |
Synonyms: | CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1 |
Type: | Protein |
Mol. Mass.: | 55774.82 |
Organism: | Homo sapiens (Human) |
Description: | P10635 |
Residue: | 497 |
Sequence: | MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
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BDBM50529952 |
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n/a |
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Name | BDBM50529952 |
Synonyms: | CHEMBL315874 |
Type | Small organic molecule |
Emp. Form. | C20H14Cl3N3 |
Mol. Mass. | 402.704 |
SMILES | Clc1ccc(cc1)-c1c[nH]cc1C(c1ccc(Cl)cc1Cl)n1ccnc1 |
Structure |
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