| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 11 |
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| Ligand | BDBM50530249 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1911676 (CHEMBL4414122) |
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| IC50 | 12±n/a nM |
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| Citation |  Bagdanoff, JT; Chen, Z; Acker, M; Chen, YN; Chan, H; Dore, M; Firestone, B; Fodor, M; Fortanet, J; Hentemann, M; Kato, M; Koenig, R; LaBonte, LR; Liu, S; Mohseni, M; Ntaganda, R; Sarver, P; Smith, T; Sendzik, M; Stams, T; Spence, S; Towler, C; Wang, H; Wang, P; Williams, SL; LaMarche, MJ Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors. J Med Chem62:1781-1792 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein phosphatase non-receptor type 11 |
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| Name: | Tyrosine-protein phosphatase non-receptor type 11 |
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| Synonyms: | 3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2) |
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| Type: | Protein phosphatase |
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| Mol. Mass.: | 68443.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q06124 |
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| Residue: | 593 |
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| Sequence: | MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG
DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGK
EAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYD
VGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETT
DKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP
VSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEV
ERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHF
RTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIR
EKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGH
EYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
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| BDBM50530249 |
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| n/a |
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| Name | BDBM50530249 |
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| Synonyms: | CHEMBL4455446 | US10975080, Example 14 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H24Cl2N6O2 |
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| Mol. Mass. | 463.36 |
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| SMILES | C[C@@H]1OCC2(CCN(CC2)c2nc3[nH]nc(-c4cccc(Cl)c4Cl)c3c(=O)n2C)[C@@H]1N |r| |
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| Structure | 
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