Reaction Details |
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Target | Mitogen-activated protein kinase 1 |
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Ligand | BDBM50094464 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1923491 (CHEMBL4426447) |
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IC50 | 0.400000±n/a nM |
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Citation | Lim, J; Kelley, EH; Methot, JL; Zhou, H; Petrocchi, A; Chen, H; Hill, SE; Hinton, MC; Hruza, A; Jung, JO; Maclean, JK; Mansueto, M; Naumov, GN; Philippar, U; Raut, S; Spacciapoli, P; Sun, D; Siliphaivanh, P Discovery of 1-(1H-Pyrazolo[4,3-c]pyridin-6-yl)urea Inhibitors of Extracellular Signal-Regulated Kinase (ERK) for the Treatment of Cancers. J Med Chem59:6501-11 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase 1 |
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Name: | Mitogen-activated protein kinase 1 |
Synonyms: | ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK |
Type: | Ser/Thr Protein Kinase |
Mol. Mass.: | 41392.76 |
Organism: | Homo sapiens (Human) |
Description: | P28482 |
Residue: | 360 |
Sequence: | MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
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BDBM50094464 |
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n/a |
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Name | BDBM50094464 |
Synonyms: | CHEMBL3590107 | US10525036, Example SCH772984 | US10934304, Example SCH772984 |
Type | Small organic molecule |
Emp. Form. | C33H33N9O2 |
Mol. Mass. | 587.6742 |
SMILES | O=C(CN1CC[C@H](C1)C(=O)Nc1ccc2[nH]nc(-c3ccncc3)c2c1)N1CCN(CC1)c1ccc(cc1)-c1ncccn1 |r| |
Structure |
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