| Reaction Details |
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 | Report a problem with these data |
| Target | Peptide deformylase |
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| Ligand | BDBM50535502 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1930890 (CHEMBL4434141) |
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| IC50 | 12±n/a nM |
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| Citation |  Spletstoser, JT; Dreabit, J; Knox, AN; Benowitz, A; Campobasso, N; Ward, P; Cui, G; Lewandowski, T; McCloskey, L; Aubart, KM Discovery of piperazic acid peptide deformylase inhibitors with in vivo activity for respiratory tract and skin infections. Bioorg Med Chem Lett29:2410-2414 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peptide deformylase |
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| Name: | Peptide deformylase |
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| Synonyms: | DEF_STAAM | PDF | Polypeptide deformylase | def | def1 | pdf1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 20556.80 |
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| Organism: | Staphylococcus aureus |
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| Description: | P68825 |
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| Residue: | 183 |
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| Sequence: | MLTMKDIIRDGHPTLRQKAAELELPLTKEEKETLIAMREFLVNSQDEEIAKRYGLRSGVG
LAAPQINISKRMIAVLIPDDGSGKSYDYMLVNPKIVSHSVQEAYLPTGEGCLSVDDNVAG
LVHRHNRITIKAKDIEGNDIQLRLKGYPAIVFQHEIDHLNGVMFYDHIDKNHPLQPHTDA
VEV
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| BDBM50535502 |
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| n/a |
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| Name | BDBM50535502 |
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| Synonyms: | GSK-1322322B | GSK1322322 | GSK1322322B | Lanopepden |
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| Type | Small organic molecule |
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| Emp. Form. | C22H34FN7O4 |
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| Mol. Mass. | 479.5483 |
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| SMILES | [H][C@@](CC1CCCC1)(CN(O)C=O)C(=O)NNc1nc(C)nc(N2CCN3CCOC[C@]3([H])C2)c1F |r| |
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| Structure | 
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